Evaluation of Phytochemical Screening, GC-MS Analysis and Anti-Bacterial Potentiality of Terminalia chebula Fruit

Abstract

India is renowned for its native plant Terminalia chebula (Combretaceae), known for its extensive therapeutic and ethnomedicinal properties. This study aimed to evaluate the phytochemical composition and antibacterial efficacy of its fruit extracts using the agar well diffusion method. The crude fruit extract and its fractions exhibited notable antibacterial activity, particularly the methanol extracts, prompting GC-MS analysis. This analysis revealed ten different phyto-compounds, with 1, 2, 3-Benzenetriol (44.52% area percentage) and Quinic acid (17.47% area percentage) being the predominant compounds. These compounds are associated with diverse medicinal properties including anti-diabetic, antioxidant, anti-inflammatory, anti-cancer, and antimicrobial effects. These findings underscore the considerable antibacterial potential of T. chebula and its rich chemical composition, offering insights into its phytochemical profile for potential pharmaceutical applications.